Why are we doing this study?
The purpose of this clinical trial is to investigate the efficacy and safety of a new investigational medicine called setrusumab in pediatric and young adult patients with OI Types I, III, or IV.
“Investigational” means setrusumab is not approved by Health Authorities and is still being tested in research studies. Current treatments for OI focus on preventing bone from breaking down (bone resorption). However, bone remains abnormal, and some patients still experience fractures.
Setrusumab is an investigational therapy that works differently than bisphosphonates. We are performing this study to see if treatment with setrusumab will reduce the total number of fractures a patient with OI experiences.